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This is a list of Latter Day Saints who have attained levels of notability. From Wikipedia, the free encyclopedia. This article includes a list of references , but its sources remain unclear because it has insufficient inline citations.

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This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately , especially if potentially libelous or harmful. July Learn how and when to remove this template message. Mormon art and List of Utah artists. Bascom , cowboy artist and sculptor Milo Baughman , modern furniture designer [1] Johan Benthin , Danish painter and sculptor [ citation needed ] Joseph Brickey , American painter [ citation needed ] Blair Buswell , American artist [ citation needed ] C.

Christensen , Danish-American pioneer artist [ citation needed ] James C. Fairbanks [ citation needed ] John B. Fairbanks , muralist; father to Avard Fairbanks [ citation needed ] Ortho R. Fairbanks , American sculptor; grandson of John B.

Knaphus , Norwegian-born artist and sculptor [ citation needed ] Giovanna Lacerti , Italian artist [ citation needed ] Alfred Lambourne , English-born artist [ citation needed ] Howard Lyon , American artist [3] Fannie Nampeyo , Hopi potter [ citation needed ] Helen Naha , Hopi potter [ citation needed ] Greg Olsen , painter [ citation needed ] George M.

Ottinger , artist, educator and actor [ citation needed ] Del Parson , American painter [ citation needed ] Hadi Pranoto, Indonesian batik maker [4] [ importance? Watts , American artist and sculptor [ citation needed ] Dan Weggeland , Norwegian-born artist; art teacher [ citation needed ] Mahonri Young , sculptor [9]. Willard Marriott [] Larry H. Lee , Brigham Young University president — ; inaugural J. Bailey , mathematician [ citation needed ] Nathaniel Baldwin , telephonic headphone inventor [ citation needed ] John Moses Browning , gun designer [] Jonathan Browning , gunsmith, inventor; father of John Moses Browning Val A.

Farnsworth , inventor of the cathode ray television [] H. Tracy Hall , invented synthetic diamonds [] Robert B. Ingebretsen , co-developed digital audio recording; Academy Award recipient [] Don Leslie Lind , astronaut [] Yukihiro Matsumoto , chief designer of Ruby programming language [] Orson Pratt , mathematician and astronomer [ citation needed ] Alvino Rey , invented the pedal steel guitar [] James LeVoy Sorenson , inventor [] James E.

Talmage , scholar, scientist [ citation needed ]. Bush; co-wrote Bush's autobiography [ full citation needed ] Paul A. List of Medal of Honor recipients. Army, Korean War [ citation needed ] Leonard C. Army, Vietnam War converted in [ citation needed ] Bernard F. Army, War in Afghanistan [ citation needed ] Junior N. Van Noy , U. Navy, World War II [ full citation needed ].

Latter Day Saint political history. King D—Utah, —41 [] Frank E. Bangerter R—Utah, —93 [ citation needed ] Henry H. Mabey R—Utah, —25 [ citation needed ] Scott M. Matheson D—Utah, —85 [ citation needed ] Herbert B. Terrel Bell , U. Reuben Clark , Undersecretary of State , U. Secretary of Treasury —71 ; U. Assistant Secretary of Treasury —21 , U. Commissioner of Customs —39 , Special Assistant to U.

Secretary of Treasury —40 Gregory J. Ambassador to Denmark —99 [] Matthew H. Ambassador to Yemen —present ; U. Ambassador to Kuwait — Stewart Udall , U. Secretary of the Interior —69 [] [ not in citation given ].

Smith , also member of Utah territorial legislature Heber J. Kimball Ezra Taft Benson , also U. Secretary of Agriculture Howard W. List of Prophet-Presidents of the Community of Christ. Wallace Smith Wallace B. Grant McMurray Stephen M. Leslie Broadbent John Y. Merril Jessop de facto leader.

List of denominations in the Latter Day Saint movement. Milo Ray Baughman, Jr". Archived from the original on April 15, Retrieved June 3, Retrieved 16 November Retrieved May 9, The Soul of Rural Utah".

Salt Lake City, Utah. Garr ; Donald Q. Cannon ; Richard O. Encyclopedia of Latter-day Saint History. Salt Lake City, Utah: Sculptor of His Heritage". The Ziggy Ansah Conversion Story". Retrieved 20 December Retrieved 26 January Raider in the Booth Archived at the Wayback Machine.

Archived from the original on Retrieved 6 October Archived from the original on October 9, Retrieved 14 January Retrieved June 24, Haloti Ngata mourns his mother while preparing for NFL draft". The Register-Guard Eugene, Oregon. Archived from the original on 3 December The New York Times.

Training camp all football all the time". Retrieved February 6, Retrieved September 6, Famous HR was key, but Vern Law played a role, too". Baseball MVP, mission president, governor? Archived October 21, , at the Wayback Machine. Archived from the original on 7 July Retrieved January 26, Mad Dog Mark Madsen web site.

Archived from the original on December 15, Volleyball and beach volleyball". Archived from the original on January 29, The Sydney Morning Herald. The Salt Lake Tribune. Archived from the original on February 9, Univ of Utah - Encoded Archival Descript…". Archived from the original on 14 July The San Francisco Chronicle.

Iressa - FDA prescribing information, side effects and uses

Sam Coupland was part of the winning team and may well be the first Southport Waterloo athlete to make it to a Schools CE final; certainly in living memory. And to top it off, Sam's pentathlon total of was a new Club Record! Katie ran a Season's Best m in 2: Junior Boy Sam Coupland ran That gave him a new Pentathlon PB of points.

A great score and a worthy new club record. Luke Suarez and Drumayne Moore competed as Inter Boys, both competing a number of events outside their comfort zones as sprinters. One additional point of interest. Combined Events has not had much of a profile in Merseyside Schools for a number of years and they had no Team Manager.

Step forward Barrie Hughes and now we are seeing some success. Its not just our athletes that make the news on this site. This was the first time any England Athletics team had competed in Guernsey where they were up against a composite senior Channel Islands Senior Team and Scotland Junior Team as well as guest athletes. The team flew out from Stanstead and Manchester on Friday evening, returning back early Sunday morning. Both the men's and women's teams won their respective matches and the women's relay team briefly had the fastest time for any Under 20s team this year, until this was taken on Sunday by a GB Under 20 team in Mannheim!

This was Graham's second international this season after attending the Loughborough International as an England Senior Team Sprints Coach at the start of the season. With many of our young athletes taking part in Combined Events competition, including quadrathons for younger members, it was perhaps a natural progression to try hosting a QuadKids competition ourselves. The idea came from Barrie Hughes who organised Friday's event, solely for club members.

It was a gloriously sunny afternoon and it was clear that all the kids and the officials, parents and coaches enjoyed it..

Under 9s Amber Cliff and Harry Clark. Under 11s Renee Adams and Joseph Wake. Under 13s Amber Hughes and Rhys Hulse. Under 15s Katie Piercy and Harry Lyons. Under 11 Joseph Wake's points earned him the Silver standard as did Jamie Simpson's score; just 2 points between 1st and 2nd. Under 13 Amber Hughes scored a massive points achieving the Gold standard. Under 13 Rhys Hulse scored an impressive points, a Gold standard, with 2nd placed Jack Clark and 3rd placed Sammy Pickerill achieving the Silver standard.

Under 15 winner Katie Piercy scored points, another Gold standard. As this was an intraclub event and not a permitted open meeting the results won't go to Power of Ten but all the athletes can be pleased with their performances. And hopefully the event can be extended next year with young athletes invited from other clubs. The team includes four members of Southport Waterloo. Some will be disappointed but, realistically, this is probably the best that could be achieved this year.

This is the strongest team Merseyside has put together for a number of years with only those with Entry Standards considered. We wish them all well. The 3rd fixture of the YDL lower for U13s and U15s saw the team head north to the top of Cumbria, namely the Sheepmount Stadium in Carlisle, which had finally reopened in March following its drawn out repairs and rebuilding after being badly damaged by the floods of December With numbers in the team slightly down on the first 2 fixtures and with Team North Cumbria hosting this match, this was a match that everyone knew would be difficult to win.

Surprisingly though, TNC didn't field as big a team as expected and a strong performance from our 29 athletes combined with the all important 55 points for a full team of officials saw us win the match in the end, although we were run very close by the host club. The final scores were Southport Waterloo With Bury only finishing 4th, this means that they are now 8 points adrift of us in 3rd place in the league table and with 2 teams to be promoted, we have guaranteed ourselves 1 of those places going into the final fixture so next years fixtures will be played in West 1.

In terms of performances on the day 2 really stood out, the 2 which broke club records. Sierra Jalloh ran an outstanding grade 1 Overall there were 28 graded performances and 32 PB's across all 4 age groups. Such is the quality in this age group at the moment that there were 5 event wins, 4 B event wins and no less than 11 graded performances. Amber took maximum points in all 3 of her events and all were grade 1 standards, winning the 70m Hurdles in Sierra did exactly the same as Amber, winning the 75m in a grade 1 Grace was the B athlete in both sprints and took maximum points in both with In addition she also ran as B runner in the m following a late withdrawal and finished in 4: Rachel also featured in the , finishing just 0.

Libby stepped up to the A race in the m and she finished in 2: Jessica ran a very good Hurdles race but was just beaten into second place, with both being given the same time of Jessica and Evie also both ran in the Non Scoring 75m too, running In the field, Jenna extended her Javelin PB by 72cm to In the first 2 fixtures, the 4x quartet of Jessica, Grace, Amber and Sierra won the race with ease and today was no exception with Sierra bringing the baton home in Just the 1 event win here with Rhys winning the Long Jump with 4.

Even better though was his m; running it for the first time this year, he took nearly 3 seconds off his PB to come home 3rd in a Grade 1 His final event was the high jump, in which he cleared 1. Sammy was leading a close fought for most of the race but was just pipped to the line, with both athletes being given the same time of 2: Sammy also contested the Shot and Javelin for the first time in competition, throwing 3.

Marcus fell at the first in his hurdles race but quickly got back on his feet to finish in He also ran a Will O'Donnell contested 3 track events, equalling his PB in of Will Collins also ran the , finishing in 5: He also long jumped 3. Katie improved her PB in the Hurdles, running She also threw 7. Niamh extended her Long Jump PB to 4. In the high jump she cleared 1. Millie scored valuable points in the throws, with Eleanor also threw the Hammer for the first time and finished 3rd B in 5.

Chloe also ran the in a PB Throwing the Discus for the first time in competition, she also finished 3rd B with 7. Hannah ran the hurdles in At the end of the day, Hannah, Niamh, Millie and Katie ran the 4x in The Under 15 Boys also featured 9 athletes. In common with the U13 Girls there were 5 event wins, 4 B event wins and 11 graded performances. Joe Kane continues to run Grade 1 times consistently in the short sprints and today was no exception.

He finished 2nd in the in Ethan won the B in a PB Josh was the B runner in , equalling his grade 3, He also won the B Long Jump with 4. Leo has been training twice a week for the Hammer and has increased his PB enormously over the course of this season. No PB today but his grade 3 throw of He did improve his PB in the shot though by 27cm, with 8. On the track he also ran the in 2: Tom Murphy ran the for the first time to score some extra points for the team and finished in 2: Earlier on Tom won the 80m Hurdles in a PB equalling, grade 4 Jonathon finished 2nd in the B hurdles in a PB Being unable to run at the moment, Joe Sutton concentrated on the throws and was rewarded with 3 PB's from his 3 events.

The last of the 3 was Javelin and he threw 1. James also threw a PB in the Javelin of Wigan had opened up a huge gap between them and everyone else by the end of the first leg but this was gradually pulled back over the second and third legs, leaving Sam to take the lead m from the finish.

As already mentioned, the time of 2: While it was a long day it was certainly worth it. Full results Results for Southport Waterloo athletes. A brilliant result for team manager Graham Boreham and for all the boys and girls who have supported the team. All will be delighted to know that they have been shortlisted for a Sefton 'Team of the Year' award. This race, 4th in the club's Fell Grand Prix series,is described as a challenging 5.

There were a number of stiff ascents to climb during the race, the first of which comes right from the start when the runners climb along the road for half a mile before getting onto the fell. The course then took a gradual climb over the very dry fell to a fast road descent, which the runners have to come back up towards the end of the race. After the descent the course joined the fell again to start the main climb up to the Weets summit. It was then across the fell before the fast tarmac road descent to the finish.

The warm dry conditions made for good fast running which resulted in a new course record of Olivia had already attained the entry standard for English Schools for the 1,m and this Triathlon is a major event for UK triathletes. Olivia was with the leaders throughout but in the later stages of the run she sprinted away to win the event by 9 seconds in a total time of A fantastic result for Olivia and we are very proud of her achievements outside of athletics.

For Junior, Inter and Senior boys and girls, this provides the basis for selection to the Merseyside team going to the English Schools National Championships in Birmingham in July, but also provides competition for Year 7s, and selection for a Merseyside team to compete against Cheshire at Ellesmere Port in July. So the meeting provided lots of opportunities to earn a county vest. The format was slightly different this year with Year 7 events in the morning and the main championships in the afternoon; but the numbers didn't justify the timetable with many races going as straight finals and long gaps between events.

Southport Waterloo athletes were there in reasonable numbers - although more were expected. I believe Merseyside Selectors were meeting on Sunday night to decide on the team going to Birmingham. But I also understand that, for the first time in quite a while, they have more than 40 athletes who have achieved the entry standard. Good for athletics on Merseyside but it may be that there is no room this year for 'near misses'. Athletes are limited to 2 events in this competition and so are likely to concentrate on their stronger events.

The fact that PBs were few perhaps reflects the small fields and, no doubt, the effect of the weather on the day. Amber Hughes fairly easy won the 70m hurdles in She also won the shot with 10m Sierra Jalloh was another event winner running She also put the shot 7m 94 for 2nd place behind Amber. Jack Clark won the m in So not just a good sprinter! Rhys Hulse was 2nd in the m race and won the long jump competition with 4m 69, a new PB for him.

Katie Piercy was brilliant in the shot setting a new club record of 9m 45 to win the event, replacing Alex Bunclark's record of 9m She also won the javelin with 24m Although not running at Bebington, Olivia Logan has run a m this year, at Stretford, in 4: Sam Coupland set a very good club record in the pole vault clearing 3 metres with his new pole. That replaces his own previous record of 2m 81 but is 5cms off the English Schools Entry Standard. He won the pole vault and was 2nd in the high jump with a clearance of 1m Entry Standard here is 1m 72 and Sam has already cleared 1m 76 this year.

Joseph Kane is a prospect for English Schools but times were just not fast enough on the day. He was 2nd in the m in However, Joseph ran Stephanie Robertson won the 80m hurdles in She also ran And she was 2nd in the long jump with 4m Megan Howarth was 2nd in the javelin with 30m She has thrown 36m 60 this year but the Schools Entry Standard is 38 metres. Harry Flanagan was a double sprint champion winning both the m, in a Qualifying time of He has already run Darion Moore took two medals, 2nd placed in the m in Full results when available Results for Southport Waterloo athletes.

James Tartt ran a good race at Birkenhead Park on Wednesday evening finishing 2nd in The club had 5 runners in this Merseyside Grand Prix event. Mike Walker ran B'head Park results Merseyside GP.

With the increased interest and participation within the club in combined event competition, it is pleasing to note that five of our teenage athletes have been selected to represent Merseyside Schools at the North West Schools Combined Events weekend in Stockport on 23rd and 24th June. We will be back there for Round 3 next month, then hosted by Burnley which makes 2 visits in one season when the club hasn't competed here for over 10 years, in the days of the old McDonald's Young Athletes League.

Patients taking warfarin should be monitored regularly for changes in prothrombin time or INR. Based on its mechanism of action and animal data, Iressa can cause fetal harm when administered to a pregnant woman.

In animal reproductive studies, oral administration of gefitinib from organogenesis through weaning resulted in fetotoxicity and neonatal death at doses below the recommended human dose see Animal Data.

Advise pregnant women of the potential hazard to a fetus or potential risk for loss of the pregnancy. The background risk of major birth defects and miscarriage for the indicated population is unknown; however, the background risk in the U.

It is not known whether Iressa is excreted in human milk. Animal studies indicate the gefitinib and its metabolites are present in rat milk at a concentration higher than those in maternal plasma.

Because of the potential for serious adverse reactions in nursing infants from Iressa, advise women to discontinue breast-feeding during treatment with Iressa. Based on its mechanism of action and animal data, Iressa can cause fetal harm when administered to a pregnant woman [see Use in Specific Populations 8.

Advise females of reproductive potential to use effective contraception during treatment with Iressa and for at least two weeks following completion of therapy. Iressa may result in reduced fertility in females of reproductive potential [see Nonclinical Toxicology The safety and effectiveness of Iressa in pediatric patients have not been established. No overall differences in safety were observed between patients 65 years and older and those younger than 65 years.

There is insufficient information to assess for differences in efficacy between older and younger patients. No clinical studies were conducted with Iressa in patients with severe renal impairment. Monitor adverse reactions when Iressa is administered to patients with moderate and severe hepatic impairment. Twenty three patients were treated weekly with doses from mg to mg, and Iressa exposure did not increase with increasing dose. Adverse events were mostly mild to moderate in severity, and were consistent with the known safety profile of Iressa.

In the event of suspected overdose, interrupt Iressa, institute supportive care, and observe until clinical stabilization. The chemical name of gefitinib is 4-Quinazolinamine N - 3-chlorofluorophenyl methoxy[3- 4-morpholinyl propoxy] and the following structural formula:.

Gefitinib is a free base. The molecule has pK a s of 5. Gefitinib can be defined as sparingly soluble at pH 1, but is practically insoluble above pH 7, with the solubility decreasing sharply between pH 4 and pH 6.

In non-aqueous solvents, gefitinib is freely soluble in glacial acetic acid and dimethyl sulfoxide, soluble in pyridine, sparingly soluble in tetrahydrofuran, and slightly soluble in methanol, ethanol The inactive ingredients of the tablet core of Iressa tablets are lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, povidone, sodium lauryl sulfate and magnesium stearate.

The tablet coating is composed of hypromellose, polyethylene glycol , titanium dioxide, red ferric oxide and yellow ferric oxide. The epidermal growth factor receptor EGFR is expressed on the cell surface of both normal and cancer cells and plays a role in the processes of cell growth and proliferation.

Some EGFR activating mutations exon 19 deletion or exon 21 point mutation LR within NSCLC cells have been identified as contributing to the promotion of tumor cell growth, blocking of apoptosis, increasing the production of angiogenic factors and facilitating the processes of metastasis.

Gefitinib reversibly inhibits the kinase activity of wild-type and certain activating mutations of EGFR, preventing autophosphorylation of tyrosine residues associated with the receptor, thereby inhibiting further downstream signaling and blocking EGFR-dependent proliferation. Gefitinib also inhibits IGF and PDGF-mediated signaling at clinically relevant concentrations; inhibition of other tyrosine kinase receptors has not been fully characterized.

Food does not alter gefitinib bioavailability to a clinically meaningful extent. Iressa can be administered with or without food. Gefitinib is extensively distributed throughout the body with a mean steady state volume of distribution of L following intravenous administration.

Gefitinib is a substrate for the membrane transport P-glycoprotein P-gp , but it is unlikely to influence gefitinib absorption as P-gp is saturated at higher concentrations. Gefitinib undergoes extensive hepatic metabolism in humans, predominantly by CYP3A4.

Three sites of biotransformation have been identified: Eight metabolites were identified in human plasma. Only O-desmethyl gefitinib has exposure comparable to gefitinib. Gefitinib is cleared primarily by the liver, with total plasma clearance and elimination half-life of 48 hours after intravenous administration.

Daily oral administration of gefitinib to cancer patients resulted in a two-fold accumulation compared to single dose administration. Steady state plasma concentrations are achieved within 10 days after daily dosing. Age, gender, body weight, ethnicity or renal function: No dose adjustment based on patient gender is recommended.

In a study comparing 13 patients with liver metastases and moderate hepatic impairment to 14 patients with liver metastases and normal hepatic function, the systemic exposure of gefitinib was similar [see Warnings and Precautions 5. CYP2D6 metabolizes gefitinib to O-desmethyl gefitinib in vitro.

In healthy CYP2D6 poor metabolizers, O-desmethyl gefitinib concentration was not measurable and the mean exposure to gefitinib was 2-fold higher as compared to the extensive metabolizers.

This increase in exposure in CYP2D6 poor metabolizers may be clinically important because some adverse drug reactions are related to higher exposure of gefitinib. No dose adjustment is recommended in patients with a known CYP2D6 poor metabolizer genotype, but these patients should be closely monitored for adverse reactions.

The impact of CYP2D6 inhibiting drugs on gefitinib pharmacokinetics has not been evaluated. However, similar precautions should be used when administering CYP2D6 inhibitors with Iressa because of the possibility of increased exposure in these patients. An exploratory exposure response analysis showed an increase in the incidence of interstitial lung disease ILD with a greater than 2 fold increase in the gefitinib exposure [see Warnings and Precautions 5.

Co-administration of high doses of ranitidine with sodium bicarbonate to maintain the gastric pH above pH 5. Gefitinib has been tested for genotoxicity in a series of in vitro bacterial mutation, mouse lymphoma, and human lymphocyte assays and an in vivo rat micronucleus test. Under the conditions of these assays, gefitinib did not cause genetic damage. The clinical relevance of these findings is unknown. The efficacy and safety of Iressa for the first-line treatment of patients with metastatic NSCLC containing EGFR exon 19 deletions or LR substitution mutations was demonstrated in a multicenter, single-arm, open-label clinical study Study 1.

Duration of response DOR was an additional outcome measure. The median duration of treatment was 8. Efficacy results from Study 1 are summarized below. The response rates were similar in patients whose tumors had EGFR exon 19 deletions and exon 21 LR substitution mutations.

Two partial responses were observed in both patients whose tumors had GX substitution mutation with duration of response of at least 2.

One of two patients whose tumors had LQ substitution mutation also achieved a partial response with duration of response of at least 2. The results of Study 1 were supported by an exploratory analysis of a subset of a randomized, multicenter, open-label trial Study 2 conducted in patients with metastatic adenocarcinoma histology NSCLC receiving first-line treatment.

Patients were randomized 1: The median duration of treatment for Iressa-treated patients was 9. The median duration of response was 9. Iressa mg tablets are round, biconvex, brown film-coated, debossed with "Iressa " on one side and plain on the other side. Bottles of 30 Tablets NDC Advise patients to immediately contact their healthcare provider for new onset or worsening of pulmonary symptoms such as dyspnea, cough and fever [see Warnings and Precautions 5.

Inform patients that they will need to undergo lab tests to monitor for liver function. Advise patients to contact their healthcare provider to report any new symptoms indicating hepatic toxicity [see Warnings and Precautions 5. Advise patients that Iressa can increase the risk of gastrointestinal perforation and to seek immediate medical attention for severe abdominal pain [see Warnings and Precautions 5. Severe or Persistent Diarrhea: Advise patients to contact their healthcare provider for severe or persistent diarrhea [ see Warnings and Precautions 5.

Ocular Disorders including Keratitis: Advise patients promptly to contact their healthcare provider if they develop eye symptoms, lacrimation, light sensitivity, blurred vision, eye pain, red eye or changes in vision [see Warnings and Precautions 5. Bullous and Exfoliative Skin Disorders: Advise patients that Iressa can increase the risk of bullous and exfoliative skin disorders and to seek immediately medical attention for severe skin reactions [see Warnings and Precautions 5.

Advise pregnant women of the potential risk to a fetus or potential risk for loss of the pregnancy [see Warnings and Precautions 5.

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